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Apart from the well-documented GPx-like catalytic activity, ebselen is also reported for directly scavenging the biologically relevant ROS (like peroxyl and singlet oxygen) and reactive nitrogen species (peroxynitrite) with rate constants comparable to standard antioxidants
The appropriate response to that uncertainty is not to abandon the compound but to use it within a structured clinical framework: defined goals, evidence-appropriate dosing, quality-assured sources, systematic monitoring, and ongoing reassessment as the science matures
Echaniz-Laguna A, Biancalana V, Gaignard P, Chanson JB BMJ case reports 2018
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