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If youve tried diet and exercise repeatedly without lasting results, medication can provide the additional support you need

Moreover, negative media coverage or reports of adverse events can lead to increased scrutiny from regulatory bodies and public hesitation, hindering acceptance in the mainstream healthcare setting

Although guidelines suggest cautious use in compensated cirrhosis and avoidance in decompensated liver disease, a large retrospective cohort study found no significant drug-induced liver injury from naltrexone and no attributed decompensations, supporting its use in both compensated and decompensated cirrhosis with close monitoring [120,121]

Effects of tirzepatide on circulatory overload and end-organ damage in heart failure with preserved ejection fraction and obesity: a secondary analysis of the SUMMIT trial