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Mechanistically, macrophage-specific inhibition of GLUL leads to accumulation of succinate and HIF-1 via glutamine-dependent -aminobutyric acid (GABA) shunting (thereby inhibiting vessel sprouting and metastasis) and via stimulation of T effector cells

The K1 cell line is a BRAF V600E -PI3KCA mutant, MDA-T32 is a BRAF V600E -TERT promoter mutant, and MDA-T68 is a NRAS and TERT promoter mutant, whereas TPC1 does not possess RAS or BRAF mutations

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Curcumin, a natural antimicrobial agent with strain-specific activity