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During the catalytic cycle of GPX4, the active selenol (-SeH) is oxidized by peroxides to selenenic acid (-SeOH), which is then reduced with glutathione (GSH) to an intermediate selenodisulfide (-Se-SG)

Importantly, oligodendrocyte generation and myelin formation also occur in an activity-independent manner, contributing to baseline sheath maintenance and neuronal support even when myelination is not explicitly driven by experience-dependent activity (Bonetto et al., 2020)

Mechanism of Action AOD9604 has been investigated for its interaction with beta-3 adrenergic receptor pathways in adipose tissue

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