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[19] By sequential fractionation of LPS-activated macrophage medium, measuring cachectin activity at each step, Beutler purified cachectin to homogeneity

[PubMed] [PMC] Zhang T, Ai D, Wei P, Xu Y, Bi Z, Ma F, Li F, Chen X, Zhang Z, Zou X, Guo Z, Zhao Y, Li J-L, Ye M, Feng Z, Zhang X, Zheng L, Yu J, Li C, Tu T, Zeng H, Lei J, Zhang H, Hong T, Zhang L, Luo B, Li Z, Xing C, Jia C, Li L, Sun W, Ge W (2024) The subcommissural organ regulates brain development via secreted peptides

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