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In the duodenum, pancreatic enzymes degrade the R-protein-B12 complexes, freeing B12 to bind with intrinsic factor (IF) , a glycoprotein produced by gastric parietal cells in the stomach lining
However, normalization of blood parameters does not mean that the damaged tissue has been repaired
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While I have never used expired b12 vials since a pharmacist told me not to I have used multi-use vials after 28 days when they are supposed to be discarded and unrefrigerated once opened as well
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