Melanotan I is a synthetic linear tridecapeptide analogue of alpha-melanocyte-stimulating hormone, sequence Ac-Ser-Tyr-Ser-Nle-Glu-His-D-Phe-Arg-Trp-Gly-Lys-Pro-Val-NH (CHNO, 1646.9 g/mol, CAS 75921-69-6), catalogued in the literature as afamelanotide, as NDP-alpha-MSH, and in analogue notation as [Nle, D-Phe]-alpha-MSH
However, individual responses vary considerably, and some patients experience persistent digestive symptoms requiring management strategies or dose adjustments
Both medications may lead to side effects such as nausea, vomiting, and gastrointestinal upset, which should be discussed with a healthcare provider
Harkany T, Guzmn M, Galve-Roperh I, Berghuis P, Devi LA, Mackie K, et al