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The American journal of clinical nutrition
NAD preservation drives downstream metabolic benefits
Because the peptide occurs naturally in human plasma (at roughly 200 ng/mL in young adults, declining to approximately 80 ng/mL by age 60), topical supplementation essentially restores youthful local concentrations in treated skin
Clinical deficiency with clearly low blood levels affects a smaller percentage, but a much larger group falls into a gray zone where levels are low enough to cause subtle symptoms without triggering an obvious diagnosis
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