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Long-term consequences of chronic alcohol use also include other health-related illnesses, such as high blood pressure, heart and liver disease, and Alcohol Use Disorder 2

21 For example, lactate-induced H3K18la in CD4 + T cells and macrophages boosts CD39, CD73, and CCR8 gene expression, thereby leading to heightened regulatory T (Treg) cell infiltration in GBM and weakening chimeric antigen receptor (CAR)-T immunotherapy effectiveness

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