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In March 2025, the FDA approved Sanofi/Alnylam Pharmaceuticals Qfitlia (fitusiran), an RNAi therapeutic to prevent or reduce the frequency of bleeding episodes in adult and paediatric patients (aged 12 years of age and over) with haemophilia A or B, with or without factor VIII or IX inhibitors

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(2016c) observed a strong interaction between ELA and bacterial DNA, a negatively charged polymer, through electrostatic attraction and hydrophobic interaction

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