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When combined with retatrutide, exercise can enhance body composition and health
By stimulating these two hormone pathways simultaneously, tirzepatide regulates appetite, slows gastric emptying, improves insulin sensitivity, and promotes fat mobilization, producing greater, more sustained weight loss than GLP-1-only therapies like semaglutide
In participants with overweight or obesity, once-daily oral semaglutide 25 mg treatment compared with placebo led to greater improvements in glycemic parameters, including HbA1c, fasting plasma glucose, and fasting serum insulin, as well as CV risk factors such as C-reactive protein and serum triglycerides
However, the small sample-size, the short treatment period, the absence of control groups, the lack of liver biopsy evaluation after treatment are just some of the limitations of these studies
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