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5 These risk reductions were more pronounced in the cohorts with psoriasis compared to persons with obesity or diabetes without psoriasis, suggesting a direct causal benefit of GLP-1RAs
Semaglutide is also known to suppress appetite, which can lead to reduced calorie intake and weight loss
The small-molecule nature of orforglipron provides manufacturing advantages (conventional chemical synthesis rather than peptide synthesis), stability advantages (no cold chain required, room temperature storage), and formulation flexibility (simple oral tablet, no SNAC enhancer)
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