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doi:10.1038/nrm.2017.125 57

Use short, fine needles and rotate sites between the abdomen, outer thigh, and upper arm to reduce local irritation

doi: 10.1016/j.pt.2018.07.011 21 GoldschlagerN.EpsteinA

TML is then hydroxylated by 6-N-trimethyllysine dioxygenase (TMLD), which is located in the mitochondrial matrix, to form 3-hydroxy-6-N-trimethyllysine (HTML)