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Animal Model:Neonatal Sprague-Dawley rats (male, 18-22g, postnatal day 7), hypoxic-ischemic brain damage (HIBD) model [2] Dosage:100 mg/kg Administration:Intraperitoneal injection, once daily, for 14 consecutive days starting 24 hours after HIBD induction Result:Brain injury: Reduced infarct volume by 40% compared to the HIBD control group as measured by triphenyltetrazolium chloride (TTC) staining
In patients without anemia, cyanosis first appears at methemoglobin concentrations of about 15%
Kuriki et al
A functional transcriptomic analysis of peripheral blood mononuclear cells in centenarians showing increased levels of BCL-xL at the cellular and organismal levels and supporting the role of this anti-apoptotic protein in exceptional ageing across evolution
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