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BPC-157 has been investigated for inflammatory bowel disease mechanisms including ulcerative colitis and Crohn's disease models, showing reduced mucosal inflammation and accelerated intestinal healing

In PDR, long noncoding RNA PPT2-EGFL8 functions as a miR-423-5p sponge, suppressing hypoxia-induced hRMECs proliferation and ameliorating pathological neovascularization in STZ-induced diabetic mice models by modulating PPARD/ANGPTL4 signaling, thereby illustrating the targeted efficacy of miRNA sponges in addressing advanced DR pathologies (140)