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The sixth is cardiometabolic indication expansion

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Luck MR, Jeyaseelan I, Scholes RA

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In addition, Fe 2+ is a cofactor of lipoxygenases (LOXs) that catalyzes PUFA-containing phospholipids into pro-ferroptotic lipid peroxidation (Yang et al., 2016)

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In vitro, it upregulates extracellular matrix genes (COL1A1, elastin, decorin) while suppressing inflammatory cytokines

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