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The mechanism is clear
In addition to the US FDA approved GLP-1RAs, there are GLP1/glucagon dual agonists (Cotadutide, BI 456906), GIP/GLP1 dual agonists (Tirzepatide, GIP/GLP peptide I and II), GIP/GLP1/glucagon tri-agonists (HM15211, GGG tri-agonist) and GLP1R agonists (Efpeglenatide, Rybelsus) currently in phase 1- III clinical trials for T2D, obesity, and NASH (MASH) treatments (12)
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By suppressing NF-B signaling, sulforaphane can reduce the production of pro-inflammatory cytokines and enzymes, such as tumor necrosis factor-alpha (TNF-), interleukin-1beta (IL-1), and cyclooxygenase-2 (COX-2)
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