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Whereas IRP1 with coordinated FeS cluster functions as aconitase, iron deficiency activates the mRNA binding activity of IRP1

In AD and PD, interventions aimed at suppressing ferroptosissuch as iron chelation, GSH replenishment, and GPX4 activationhave shown beneficial effects in preclinical models, including reduced oxidative stress, improved cognitive and motor functions, and delayed disease onset (409412)