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Nature Reviews Endocrinology, 19, 460476

A simple rotation system works best

1 Introduction Type 2 diabetes mellitus (T2DM) is a chronic hyperglycemia-induced metabolic disease ( Glucagon-like Peptide-1 (GLP-1, 3031 aa) is a natural gastrointestinal incretin hormone of the glucagon peptide family, secreted from the enteroendocrine L-cells in the distal gut to stimulate insulin secretion in response to postprandial hyperglycemia (Figure 1)