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These numbers likely understate the real-world prevalence

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When a single dose (0.2 mg/kg) daily for 3 days (0.3 mg/kg) of PQQ was administered to 10 young participants (five males and five females), the levels of trimethylamine N-oxide, a marker of perturbed energy metabolism, decreased following PQQ intake

IQ-TREE: a fast and effective stochastic algorithm for estimating maximum-likelihood phylogenies