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Upon conjugation with glutathione, the selectivity index of epothilone towards the tumor cell lines was increased by about 5.7 folds, ensuring their higher solubility, facilitating the penetration of the drugs across the plasma membrane via the ATP-Binding Cassette (ABC) proteins ABCC1 that called GSH-S-conjugate pump [6, 41, 53, 78]
Aitken M et al
OTC pain relievers can upset your stomach if you take too many, or they can even harm your kidneys if you take a large dose or continue using them for a long period of time
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