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Premature Aging and Facial Changes: Rapid weight loss associated with Ozempic use has been linked to facial volume loss, sagging skin and a more aged appearance, often referred to as Ozempic face. The reduction in fat stores may contribute to a hollowed look, and decreased skin elasticity can make wrinkles and fine lines more prominent

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It is the same logic as a loading phase followed by a maintenance phase in many research protocols: front-load to establish, then hold with less

This distribution has prompted researchers to investigate whether GLP-1 receptor agonists might offer neuroprotective effects beyond their established metabolic benefits