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Weight reduction has been linked to improved CV risk factors and complications, particularly hypertension, ASCVD, HF, AF, pulmonary hypertension, and left ventricular hypertrophy ( 3.2 Effects on hypertension and hyperlipidemia Besides their contribution to weight reduction and glycemic control, GLP-RAs were associated with BP and lipid levels reduction ( Effects on lipid profile were collected as secondary outcomes from several clinical trials

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Despite these advances, challenges persist in optimizing FR-targeting specificity to avoid hepatic sequestrationa 2023 review noted that 60% of folate-conjugated nanoparticles accumulate in liver macrophages, necessitating surface engineering with cleavable PEG chains or FR--selective ligands [64]