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Mechanisms of Action The study identified several mechanisms underlying the observed recovery: Mesenchymal cell proliferation and periosteum reactivation, which initiated new bone formation and facilitated musclebone integration

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Integrating public-health evidence with molecular mechanisms thus underscores a central conclusion of this manuscript: aging simultaneously increases exposure to stressors and reduces the capacity to compensate for them, amplifying the risk that otherwise mild biochemical perturbations contribute to pathological misfolding, inflammation, and disease progression

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