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The review traced the developmental history of GLP-1 research from the identification of the proglucagon gene in 1982 through to the contemporary landscape of GLP-1-based therapeutics across obesity, cardiovascular disease, NAFLD, neurodegeneration, and cancer biology

On Friday, the top pharmaceutical lobby called on the incoming administration and Congress to fix the law

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Key adjustments at this phase: Reduce portion sizes by 20% to 30% across all meals Add a sixth small meal if you cannot finish larger ones Move heavy carbohydrates to earlier in the day when digestion is strongest Switch to softer, easier-to-digest proteins (fish, eggs, Greek yogurt) on dose increase days Keep hydration consistent at 8 to 10 glasses per day, sipped throughout rather than gulped at meals Phase 3: therapeutic doses (10mg, 12.5mg, 15mg, weeks 13+) At higher doses, some people find eating enough to be the challenge, not eating too little