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Long-acting GLP-1 RAs, such as semaglutide and dulaglutide, may exert a more pronounced inhibitory effect on gallbladder contraction due to their extended half-lives and sustained pharmacological profiles, thereby increasing the risk of gallbladder-related AEs ( Although this study primarily focused on reports of GLP-1 RA-induced cholecystitis and cholelithiasis, we also applied the shrinkage measure method to analyze 147 concomitant medications used alongside GLP-1 RAs for signal detection (Supplementary Table S2