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Substance-use disorders Pre-clinical and mechanistic studies A large body of pre-clinical and mechanistic literature is available regarding the putative effects of GLP-1RAs on substance misuse (Supplementary Section 5): 24 for alcohol 59,60,61,62,63,64,65,66,67,68,69,70,71,72,73,74,75,76,77,78,79,80,81,82 , 8 for opiates 63,83,84,85,86,87,88,89 , 16 for stimulants, including cocaine and amphetamines 90,91,92,93,94,95,96,97,98,99,100,101,102,103,104,105 , and 4 for nicotine 106,107,108,109
If you experience any negative side effects, be sure to report to your doctor to determine if supplementation is right for you
Unlike Citrulline Malate, L-Citrulline does not contain malate and therefore lacks the added benefit of boosting ATP production through the TCA cycle
Some people may experience loose stools, urgent bowel movements, or stomach discomfort after starting treatment or increasing the dosage
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