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Semaglutide is the most familiar name in the GLP-1 conversation, so understanding the compound itself before the program wrapping around it is where a careful reader should start
In a study by Ishibashi et al., GLP-1 was shown to dose-dependently inhibit gene expression for advanced glycation end products receptor (RAGE) in HUVEC via activation of cyclic AMP pathways and decrease reactive oxygen species generation [103]
[8] demonstrated a faster rate of oral glucose appearance in blood and more than double GLP-1 and insulin levels during a mixed meal test (MMT) in subjects with PBH [8]
This activation may potentially occur through interactions with proteins such as the interesting, newly discovered cysteine-histidine-rich protein (PINCH) and integrin-linked kinase
