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The estimated fixed effects were a maximum percentage weight regain ( A ) of 75.6% (95% CI 68.5-82.7) and a recovery rate constant ( k ) of 0.0302 per week (0.0204-0.0399), corresponding to a half-life of 23.0 weeks (95% CI 17.434.0)

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Furthermore, VMH GLP-1R deletion did not significantly affect the anorexigenic effects of systemically administered exendin-4, suggesting that the VMH may not be a critical site for mediating GLP- 1RA driven appetite suppression [99]

Also, we see that, for instance, with certain individuals, when they take GLP-1 RA therapy, they might have a lot of gastrointestinal (GI) side effects