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Conclusions Recent advances in this field have highlighted the importance of GST activities and the role that these enzymes play in diverse cellular processes as well as in conferring resistance to chemotherapy

These processes not only compromise cellular bioenergetics but also trigger immune responses through sensors such as cyclic GMP-AMP synthase (cGAS) and stimulator of interferon genes (STING), or activate NOD-like receptor family pyrin domain-containing 3 (NLRP3) inflammasomes, leading to secretion of proinflammatory cytokines such as interleukin (IL)-1 (Mills et al., 2017)

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The PSM counts were used as a semiquantitative measure, enabling us to gain insights into the relative abundance of proteins in the tear fluid proteome