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Sulfonylurea drugs such as glipizide (Glucotrol XL), glimepiride (Amaryl), or glyburide (DiaBeta, Glynase)
Retatrutide, tirzepatide, and semaglutide all reduce food noise by: Increasing activity in satiety neurons (POMC/CART neurons) Decreasing activity in hunger neurons (NPY/AgRP neurons) Reducing ghrelin secretion from the stomach Slowing gastric emptying so food stays in the stomach longer The result: the food noise quiets noticeably within days of the first injection
He breaks down how GLP1based appetite suppression combines with activinpathway inhibition to drive significant fat loss while preserving lean mass
Therefore, improving one often benefits the other
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