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While a balanced diet should ideally provide all the necessary nutrients, sometimes factors like lifestyle, age, and even location can lead to deficiencies What happens if you are low in Vitamin B12

The result is a vicious cycle where declining NAD+ leads to worse metabolic function, which can lead to weight gain, which increases NNMT activity further

Results Body weight, fat mass, and cecal mass As expected, obese mice (maintained on an HFD followed by WD) had significantly higher body weights than mice continuously maintained on LD

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