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Pogacnik et al
However, the longevity community has taken sharp notice of them because obesity and metabolic dysfunction are among the most potent accelerants of biological aging
Future research should also aim to disentangle the mechanistic interplay between S accumulation, sirtuin dysregulation, and impaired insulin signaling in PD, to identify which phytomolecules are most effective in counteracting mitochondrial stress, mitophagy defects, and neuronal apoptosis
GLP-1 agonists should not be used during pregnancy or breastfeeding, and effective contraception is advised for women of childbearing potential
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