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Although brain infarction volume reduction did not reach statistical significance, motor performance in the rotarod test significantly recovered in DSIP-treated animals compared to vehicle controls confirming a functionally relevant neuroprotective effect at the behavioural level and establishing intranasal delivery as a viable route for CNS DSIP research

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Antioxidant pathways induced by NRF2 include enzymes for the reduced GSH synthesis, utilization, and regeneration

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