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In addition, human phase I and phase II metabolizing enzymes showed complex expression, changes with the strongest upregulation for the flavin-dependent monooxygenase FMO1 and the aldehyde dehydrogenase ALDH3A1 (Supplementary Figure S15)

64 NBDHEX and its analogs NBDHEX (6-[7-nitro-2,1,3-benzoxadiazol-4-ylthio]hexanol) is a recently developed compound designed as a mechanism-based inhibitor that exerts potent effects on GST

Journal of Diabetes .4 (2012) 55-67 Kurukulasuriya LR, Sowers JR

Mitochondrial dysfunction caused by defects in long-term quality control mechanisms can dysregulate the normal function and damage the structure of VSMCs, stimulate oxidative modification of lipoproteins in the vascular wall, activate the immune response to recruit monocytes, and induce cells to differentiate into macrophages that engulf retained lipoproteins [222, 223]