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With rigorous methodology, biomarker guided enrollment, optimized delivery, and careful safety monitoring, antioxidant-oriented interventions can progress from complementary approaches to validated therapeutic options that complement existing standards of care for defined ASD endophenotypes

Astaxanthin plays several key roles in redox reactions and energy balance that may protect against neurodegeneration: Antioxidant & membrane protection: Astaxanthin quenches reactive oxygen species and by embedding across lipid bilayers, protects mitochondrial and cellular membranes This oxidative support has been demonstrated in human studies with improvement in oxidative biomarkers (MDA, isoprostanes) Neurotrophic signaling: Brain-derived neurotrophic growth factor (BDNF) is important for cognitive support

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Compounds that increased luciferase activity by more than 2-fold were defined as active