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Gclm KO mice also exhibit constitutive activation of liver AMP-activated protein kinase (AMPK) pathway and nuclear factor-erythroid 2related factor 2 target genes, and show enhanced ethanol clearance, altered hepatic lipid profiles in favor of increased levels of polyunsaturated fatty acids and concordant changes in expression of genes associated with lipogenesis and fatty acid oxidation
48 weeks (titration + maintenance) 12-15 x 10 mg or 4-5 x 30 mg vials Maintenance at 15 mg weekly drives most of the total
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GSH in the ACC was positively correlated with circulating concentrations of TIMP-2 ( R = 0.539, p = 0.008)
