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doi:10.1152/physrev.00034.2006 Nauck MA, Heimesaat MM, Orskov C, Holst JJ, Ebert R, Creutzfeldt W

In a large, rigorous review of over 50 studies involving more than one million patients, metformin use in patients with type 2 diabetes was associated with a 35% reduction in risk of death from cancer, and a 27% reduction in risk of any cancer (Franciosi 2013)

At the drug concentrations produced by weekly dosing, the natural peak-and-trough cycle allows partial receptor resensitization during the trough period

This chapter of the United States Pharmacopeia establishes requirements for sterile compounded preparations, including how pharmacies must determine BUDs