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Similarly, resistance to oxidative attack increased after overexpression of GPX5 in CHO-K1 cells, and GPX5 overexpressing cells reduced lipid peroxidation levels and downstream DNA damage marker 8-OXODG levels compared to control cells (Taylor et al., 2013)

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Furthermore, the ileum of germ-free and antibiotic-treated mice showed lower Glp1r gene expression compared to controls, with higher incretin effect resistance (68)

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