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In the JAMA paper: expression of the GLP-1 receptor in the human optic nerve and GLP-1 RAinduced enhanced sympathetic nervous system activity might influence optic nerve head perfusion. =Rapid lowering of blood glucose (and rapid change in metabolic state) in persons with pre-existing retinopathy may worsen ocular microvascular conditions (though this is more established with insulin rather than semaglutide specifically)
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Together, Marks argues, this work 'established beyond any doubt, the hormonal nature of glucagon even though no endocrinological disease had yet been identified as a result of its over or under secretion' (Marks 2018)
L., Chen, S., Lutz, T
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