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For individuals with metabolic risk factors, insulin resistance, chronic inflammation, or a family history of obesity-associated cancers, GLP-1 therapy in the context of a comprehensive, physician-guided longevity programme may represent a valuable adjunct to conventional preventive medicine strategies
Common physiological factors include: increased hunger hormone signaling reduced satiety cues metabolic adaptation after weight loss changes in energy balance return of previous eating patterns The body naturally adapts to weight changes
This approach helps improve tolerability while still achieving effective results over time
10.1038/s41591-024-03169-2 19 ChenY.-R.ZweierJ
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