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52 In a large meta-analysis by Chiang et al involving 106,395 participants and 55 RCTs, GLP-1 RA therapy was associated with an increased risk of gastroesophageal reflux disease (GERD) compared to placebo, with a reported relative risk of 2.19 (95% CI: 1.483.25)
H.pylori-infected duodenal ulcer patients are subjected to massive oxidative stress as reflected by a significant decrease of erythrocytic GPx and SOD activities and elevation of plasma MDA levels
increases hypoglycaemia risk when combined with insulin or sulfonylureas Cardiovascular health Emerging evidence suggests cardiovascular benefits associated with significant weight loss and improved metabolic markers Long-term cardiovascular outcome data for tirzepatide specifically is still accumulating compared with older GLP-1 agents Gastrointestinal side effects Typically mild to moderate and temporary, particularly during dose escalation
De synthese van carnitine gebeurt voornamelijk in de lever en in de nieren, van waaruit het via de bloedbaan naar de verschillende weefselcellen wordt verspreid
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