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5 Reactive oxygen species as oxidizing agents: impact on cysteine proteinases and cellular homeostasis It has long been established that disturbances in reactive oxygen species (ROS) regulation generate highly reactive cellular environments, profoundly influencing intracellular signaling pathways and contributing to oxidative stress

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DPP-4 is also expressed in the renal proximal tubular brush border, where it regulates Na+/H 2 O reabsorption (97)

This means insulin release occurs primarily when blood glucose levels are elevated, reducing the risk of hypoglycemia compared to some other diabetes medications