Dysregulation of these pathways contributes to impaired insulin secretion, altered lipid homeostasis, hyperglycemia, and metabolic dysfunction observed in obesity and type 2 diabetes [1]
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Beyond T2D and obesity, semaglutide was also applied for other indications such as cardiovascular disease, fatty liver, chronic kidney disease, all of which have progressed to Phase 3, expanding the influence of GLP-1RAs into more medical fields
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