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We recently identified the FOXO4 p53 axis as pivotal in maintaining the viability of senescent cells, and that senescent cells can be targeted selectively with the senolytic peptide FOXO4-DRI
But the federal agency warns that these unauthorized drugs, which are illegal, pose serious health risks, adding that it still needs to evaluate them for safety, efficacy, and quality. They have not been demonstrated, through scientific trials, to provide the health benefits that they claim, according to Health Canada in an April advisory
PMID 10569624
(3) Skin Tone The same 12-week clinical trial also reported that GHK-Cu improved hyperpigmentation and overall skin appearance
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