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Animal-model evidence consistently shows local effects: angiogenesis at the injury site (VEGF upregulation), growth-factor signaling (EGF, FGF), nitric oxide pathway modulation, and accelerated tendon-to-bone interface healing in rat Achilles transection studies

These healing peptides are used for soft-tissue injuries, post-surgical repair, tendon or ligament tears, and chronic inflammation

By interrupting a key proteinprotein interaction that allows senescent cells to persist, FOXO4-DRI offers the potential to selectively eliminate those cells and thus improve tissue function, reduce inflammation, and restore aspects of youthful physiology