Its weight-loss effects are primarily achieved through several mechanisms, including central appetite regulation via hypothalamic pathways enhancing satiety, delayed gastric emptying that prolongs postprandial fullness, improvement of insulin sensitivity and metabolic homeostasis, and reduction of visceral and hepatic fat depots, which may alleviate respiratory mechanical burden and metabolic stress in OSAS (34)
Dowling, K
Methods In this single-centre, double-blind, placebo-controlled, parallel-group trial, conducted at the Profil Institut fr Stoffwechselforschung, Germany, 75 adult (aged 1864 years) participants with type 2 diabetes (eligibility: HbA 1c of 6.59.0% (47.574.9 mmol/mol)
Daniele G, Iozzo P, Molina-Carrion M, Lancaster J, Ciociaro D, Cersosimo E, et al