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Based on data from Phase 2 clinical trials including the pivotal randomised controlled trial published in The New England Journal of Medicine in 2023 (Jastreboff et al.) the most frequently reported sensations and side effects with retatrutide are largely gastrointestinal (GI) in nature

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Tryptophan at position 9 is the principal photolabile residue and oxidises readily, with tyrosine at position 2 and histidine at position 6 secondary sites of concern

A prospective study on the safety and efficacy of vascularized lymph node transplant