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One important factor influencing the efficacy of intra-articular drugs is their residence time within the joint
Hence, our findings suggest that these FDA-approved medications may have potential therapeutic benefits when used in combination therapy protocols to treat highly resistant malignancies
Subsequently, all samples were subjected to centrifugation at 1500 rpm for 15 min at 4 C, facilitating a clear delineation of the two phases: the upper (lipophilic) phase, which contains the apolar metabolites, and the lower (hydrophilic) phase, which comprises the polar metabolites of interest
J.KootstraG.KruijerW.de RidderD
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