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While lifestyle interventions are the cornerstone of obesity prevention and management, they often fail to result in sustained and meaningful weight loss (WL)

Ethics declarations Disclosure Avery Brown, Helena Sergent, Alexander Hien Vu, Helen Liu, Jason Fisher, Eduardo Somoza, Tony Mei, Jeffrey Lipman, Julia Park, Patricia Chui, John Saunders, Marina Kurian, Loic Tchokouani, George Ferzli, Christine Ren-Fielding, Manish Parikh, Megan Jenkins have no conflicts of interest or financial ties to disclose

The Science Behind Fat Metabolism At the cellular level, fat metabolism is a multi-step process that converts stored fat into usable energy